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News
17.12.2009
What is online analytics?
In line with the current thinking of the FDA, online analytics is ultimately an efficient way to manufacture biopharmaceutical drugs safely and consistently. An online analytics system uses Historian data (collected data) and scientifically sound models to make adjustments to a manufacturing process "run" in real time.
Because the adjustments are made based on the most current and accurate data available at the given time, the chances are greater for improving the quality of a cell culture product, or at least leading the given culturing process in the right direction.
The experts at Roche Innovatis AG have a broad understanding of the biopharmaceutical industry and its regulations, and, working with you, bring together the hardware, software and intellectual property necessary to deploy fully automated cell culture analysis in a process environment.
15.12.2009
Translation List Roche Innovatis Material Numbers
As a current Innovatis AG customer, you already know
the outstanding competence and support provided by Innovatis.
You have experienced how precise and effortless it is to integrate
Innovatis instruments into your workflow. Roche’s overriding aim
in acquiring this technology is to provide customers with reliable
and precise cell analyzers and reagents supported by Roche service.
We will do everything possible to maintain the service and support
you are accustomed to. As a result of our significant position in
the life sciences industry, we will strive to increase the marketing,
application and technical support available to existing and future
Innovatis customers.
Integrating Innovatis into the Roche organization increases the
exposure of this compelling technology in the marketplace. We
hope you will take advantage of our expanding cell science expertise
to explore our state-of-the-art instrument and reagent systems in
genomics and proteomics.
We will update you on a regular basis as we bring the Innovatis
expertise onboard to ensure the high level service and support you
deserve. In the meantime, your regional Innovatis representative
will continue to be at your service. Please do not hesitate to contact
them with questions during this transition period.
17.07.2009
High-Resolution Digital Imaging with Cedex HiRes from Roche Innovatis
Roche Innovatis has launched Cedex HiRes, the newest generation of image-based Cedex Cell Counter and Analyzer systems for automated cell culture analysis. Cedex HiRes measures cell density, viability, aggregation rate, cell morphology, and cell debris using the Trypan Blue exclusion method, with high-resolution digital image recognition. The exceptional image quality allows deeper insights into even the subtlest changes in a cell culture, such as monitoring baculovirus transfections for protein production via measurement of cell diameter changes. Designed to work in a production environment while strictly adhering to quality guidelines, Cedex HiRes uses software with extensive capabilities for data management and control to ensure compliance with all current Good Manufacturing Practices (cGMP) regulations.
New instrument features account for reduced operator time and increased analytical accuracy. Up to 20 individual samples of 300 µl each are handled by the multi-sampler. Cell staining and mixing tasks are fully automated, as are focus adjustments. Cedex HiRes produces images with pixel resolution of 0.8 µm, enabling the distinction of objects with a distance of less than 2 µm to each other. Detectable cell diameter range is 2 µm - 40 µm, and object diameter range of 1 µm - 90 µm. Digital image recognition allows for permanent storage of acquired data.
Developed in close collaboration with customers, the Cedex HiRes features Cedex 2 Software that simplifies the visualization, transfer and storage of the most elaborate data sets for true automation in cGMP regulated environments. Through its Systems Suitability Test (SST), Roche Innovatis provides consumables and maintenance protocols that allow users to routinely verify and document system quality and ensure measurement performance.
01.05.2009
We provide quality that automates. You improve quality of life…
Our systems are designed to automate your cell culture analysis. We support your applications in research, development and production with analyzers and software that simplify and speed up the characterization of your cell cultures.
innovatis offers a suite of analyzers that focus on the key areas important to you: validation, integration and accuracy. Our systems are designed to be validated quickly and easily within a GMP environment. To assure that your analytical data are securely captured for storage and comparison, we facilitate data integration with your existing protocols. And, innovatis is solely concerned with the cell culture analysis: our analyzers achieve accuracy unmatched by other systems.
You improve quality of life by developing cell-based vaccines, therapies and treatments. We provide quality that automates.
09.03.2009
Automated cell culture analysis in your validated bioproduction process.
Data from Cedex, CuBiAn and your other analyzers are seamlessly integrated into existing manufacturing enterprise systems enabling continuous process adjustment in near real-time. The BaychroMAT platform, together with innovatis expertise and technology, delivers online analytics.
BaychroMAT, by Bayer Technology Services, is a fully automated platform capable of sterile sample extraction directly from a bioreactor. Developed specifically for fermentation processes, it performs cyclical extraction and automated handling of defined, representative samples of the bioreactor contents with no risk of contamination.
BaychroMAT supports seamless integration of the Cedex or Cedex Hires cell count analyzers, from innovatis, to enable automated measurement of cell count and viability.
In addition to cell count and viability, IgG production and metabolite levels are measurable in an automated system. CuBiAn, also from innovatis, is a photometric biochemistry analyzer that provides robust, high throughput analyses due to its membrane-free operating principle.
For more information, contact innovatis.
16.03.2009
Roche acquires innovatis AG, Bielefeld to complement its product portfolio in the rapidly growing area of cellular analytics.
Innovatis AG (innovatis) and Roche Diagnostics today announced that they have signed a definite agreement und which Roche will acquire 100% of innovatis, a privately held company based in Bielefeld, Germany. innovatis is a leading provider of automated cell analysis solutions, especially focussing on cell counting, viability testing, and call function analysis in research, as well as bioproduction. The purchase price for this transaction is 15 million Euros.
innovatis AG is fully-owned by two private equity funds that are exclusively advised by Ventizz Capital Partners, Düsseldorf. Reinhard Löchner, Managing Partner of Ventizz, explains: “Starting as a spin-off from the University of Bielefeld, we have made a strong contribution to develop innovatis to a market-leading company for cell analysis. Today, seven years after the fund’s initial investment, most big pharma and biotech companies are listed among their customers. We are proud to having identified Roche as a perfect strategic partner to further accelerate innovatis’ operative development.”
"This acquisition is a further step in our strategy to strengthen our position as a complete solution provider in the cell analysis research market,” said Dr. Jürgen Schwiezer, CEO Division Roche Diagnostics. “Innovatis’ technology will complement the existing Roche cell analysis portfolio and is synergistic to the xCELLigence technology launched in 2008.”
Michael Grohmann, Managing Director of the innovatis AG stated “Roche has been one of our key customers for many years, in particular since the successful development of our cell analysis technology over 10 years ago. The innovatis technology is very well placed for future growth as part of Roche Applied Science.”
Innovatis will become a fully-integrated part of Roche Applied Science, a global business area of the Diagnostic Division of Roche. The company will continue to develop and market products for cell analysis through Roche Applied Sciences extensive worldwide network.
The transaction is expected to be completed within the next few weeks, subject to shareholder approval and regulatory clearance. Close Brothers acted as the exclusive financial advisor to Ventizz Capital Partners on this transaction.
13.12.2008
Cedex XS semi-automated cell counter saves time and samples
Save precious time and samples while getting an accurate cell count with Cedex XS.
Introducing Cedex XS by innovatis, a benchtop, semi-automated, image-based cell analyzer. Cedex XS is capable of delivering cell concentration, viability (using the Trypan blue exclusion method), cell morphology, cell aggregation, and growth data from sample volumes as small as 10 microliters, conserving samples and reagents. Cedex XS software is based on Cedex 2 Software, developed for fully automated Cedex Cell Analyzers that have been accepted and in use at most of the leading pharmaceutical and biotechnology manufacturing facilities worldwide.
01.12.2008
CuBiAn - Assesses all important cell culture metabolites, and IgG
CuBiAn by innovatis is a fully-automated, membrane-free chemical analyzer that measures key parameters in cell culture media, including IgG.
As a proven, established technology, the automated capabilities and membrane-free technology of CuBiAn allow for robust usage and high reproducibility, with very low operating costs in calibration and maintenance. Unique among chemistry analyzers, it is engineered and designed to integrate with the BaychroMAT CellCount, an online fermentation monitoring automation platform co-developed with Bayer Technology Services to assist bioprocess labs comply with the FDA Process Analytical Technology (PAT) Initiative.
15.12.2008
Get more that you counted on, with CASY Cell Counter + Analyzer
The CASY Cell Counter + Analyzer from innovatis is unique in that it can simultaneously measure cell count, cell viability and cell volume non-invasively.
Analysis is accomplished not with dye, but via measurement of the subtle electrical properties of the cells' membranes, i.e. Electrical Current Exclusion (ECE). The software produces a comprehensive graphic representation of the cell culture sample that neatly reveals the condition of its contents in detail, in as little as 10 seconds. The digital pulse processing technique that assures reproducible and accurate analysis for all types of mammalian cells, as well as bacteria, yeast, algae, parasites, pollen and sperm.
17.07.2008
Lifetime warranty by innovatis
Innovatis now provides a lifetime warranty for their Products.
QUALITY THAT COUNTS, engineered and MADE IN GERMANY is not only a phrase but also the Innovatis Mission.
Innovatis, the founder of the automated cell analysis and the only worldwide provider
with a solution of harmonization and qualification of cell analysis, responds to the market requirements.
With more than 10 years experience, focus and understanding of cell analysis, Innovatis is your partner for all your cell application needs.
Customers using the innovatis certified and GMP produced consumables in coordination
with preventive maintenance service contracts, acquire the benefits of a lifetime warranty.
As of June 2008, all devices meeting the terms are covered by the new warranty.
For more information, please refer to the enclosed description!
30.04.2008
Shorter measurement times with the new Cedex 2.1.2 Software
Since its introduction in the last quarter of 2007, the new software version 2.1.1 for the Cedex and Cedex HiRes systems has generated a very positive response from our customers.
However, the new software has been technically refined and optimized. As an important result the latest version 2.1.2.offers … a significant reduction in measurement time !
In the case of a standard Cedex system with an MS20 multisampler, for example, each sample can be analysed in only 2:42 minutes. So a time saving of 30 to 90 seconds per sample can be achieved.
The importance of the reduction in measurement time in the event of a maximum workload
of 20 samples is obvious: the time needed can be reduced by 30 minutes!
Similar reductions in measurement times can also be achieved with the Cedex HiRes system.
Important Note:
Innovatis is offering a free update to all interested Cedex software 2.1.1 users!
Please contact your local service and support team to set up an appointment
for an update.
For more information or further questions please contact support@innovatis.com.
16.04.2008
Rollout Cedex Software 2.1.2
After the successful market launch of the new Cedex 2 software in the summer of 2007, innovatis now presents an updated version for the optimized analysis of cells using the Cedex and Cedex HiRes systems.
What began as a joint development project between customers and innovatis now has its successor. In addition to updates based on customer feedback, the software has been technically refined, thus further improving performance.
The result is the Cedex software 2.1.2.
Innovatis is now offering a free update to all interested Cedex software 2.1.1 users!
Contact your local service and support team to set up an appointment for an update.
For more information or further questions please contact support@innovatis.com.
22.10.2007
Cedex Gets a ”New Look”
We would like to advise you in advance that it will not be long before the instrument enclosure of the Cedex will change. The reason for this is obvious!
Due to the expansion strategy of our company and the consequent variety of products, clear brand management becomes the crucial identity feature in order to be recognized in the market. This is reflected not only in the company brand but also in the product design.
For this reason all systems produced by innovatis AG will be supplied with white instrument enclosures in the future.
The color change of the instrument enclosure becomes even more important regarding the Cedex product as this change is in conjunction with the system upgrade to the latest Cedex 2 technology. This makes it easy for us, the manufacturer, as well as for the users to quickly distinguish between old and new instruments.
04.07.2007
Market launch “Cellavista” - The new platform technology for cellular analysis in microplates
At the ESACT meeting 2007 in Dresden, innovatis AG presented the Cellavista, our newest technological development in the area of analysis of cells in microplates.
The Cellavista, successor to the Cellscreen system, is a fast and flexible image-based platform technology designed to combine the advantages of brightfield imaging and fluorescence capabilities. Long-term studies with selected beta-test customers already indicate that the system has a bright future – in addition, there was a long list of companies interested in an on-site demonstration of the Cellavista by the end of the meeting in Dresden.
With its broad range of applications, the system covers all areas of cellular research and development including:
• Single cell cloning
• Cell confluence
• Suspension cell count
• FACS seeding efficiency control
• Cell nuclei count and characterization
• Transfection efficiency
• Microplate quality control
• Viral plaque assays
• Fluorescent protein expression
• Apoptosis assays
… and many more fluorescence applications
For more detailed information, brochures are available in the download area of our internet website. Alternatively, discuss your applications directly with the responsible product manager, Dr. Gerd Emde!
17.06.2007
The new Cedex 2 Software - Extended system features and new application alternatives!
This new version of the software is the result of a development project of innovatis AG in collaboration with prominent users within the pharmaceutical- and biotech sector. Compared to the currently established Cedex software, this version represents an entirely new basic version.
On the one hand, a large number of user-related requirements have been included in this new version, while at the same time, providing the market with the opportunity to be used for further application requirements in the future– thus the new Cedex 2 software represents the new platform technology for future-oriented cell culture analysis!
From the end of May onwards all new Cedex HiRes Systems will be equipped with the Cedex 2 software by the manufacturer.
Innovatis AG provides extensive up-grade options for customers already with existing systems. The modular “licence-key-system” is allowing a well-balanced cost/performance ratio for individual customer requirements. In this way, it is also possible to purchase two modul versions - a basic and a full package.
The customer benefits not only from the advantages gained through the increased automation level for his product and the optimisation of the process reliability of his analytical method, but also from the advantage of a future-oriented design of the system configuration. At present, the new software is designed in such a way, that upgrades for additional application areas are possible later on.
Likewise, the new software is also available for Cedex, the established “gold standard“ in cell culture analysis. Innovatis experts naturally provide competent support in this area for all questions asked concerning cGMP-aspects. So the customer still remains “on the safe side” within his validated method.
For further information please contact your sales representative directly. The respective contact details are listed on our web site “Contact world wide” under the appropriate country symbol!
01.12.2006
CEDEX and CASY Technology – two strong brands are coming together
Innovatis AG, Bielefeld, and Schärfe System GmbH, Reutlingen,
jointly announce
Founded in 1995, innovatis AG ranks among the leading suppliers of systems solutions for process analytics in biotechnology. With the development of the CEDEX automated cell analyzer, innovatis AG early on recognized the market requirements of the future and revolutionized the manual cell counting process previously established in the market. The Cedex, based on an image recognition measurement procedure using the Trypan blue method to determine viability, is now internationally recognized as the “Gold Standard” for cell counting in both biotechnology and R&D within the pharmaceutical industry.
21.08.2006
Integration Services are the Latest Trend
The pharmaceutical industry is experiencing continuously increasing pressure to economize. In order to achieve economization, a high degree of standardization, efficient automation and a well networked information management are required. In doing so already 50 % of the turn-over is generated solely by 20 worldwide operating companies. For the information management, economization on a global scale doesn’t just signify a local computer-network – but rather demanding answers to the challenges presented by locations spread across the world and the linkage of information from various fields. [...]
21.08.2006
Lost in PAT?
In 2004 the initiative Process Analytical Technology (PAT) was enacted by the regulatory authority Food and Drug Administration of the United States of America (US FDA). This initiative is causing a shift in direction away from strictly specified requirements and decision criteria towards decision-making in the pharmaceutical and biopharmaceutical industry, which is based on scientifically proven methods. [...]
21.08.2006
Process Validation is a planable standard method these days…
After the twentieth validation in Europe, North America and Asia-Pacific a CEDEX validation process of constantly high quality takes only 4 days per instrument! [...]
27.07.2006
Cedex HiRes
Measurement time can be significantly shortend.
Results of cooperation with Hochschule Wädenswill, Switzerland
27.02.2006
Cedex - new High Speed Multi Sampler
Discontinued Autosampler AS20 replaced by our new Multi Sampler Generation.